Jarod Miller, Jason Lezak, Ra Ra Riot

S16 E01 • Tuesday, Sep 2, 2008 • Sep 2

Nicolas Cage, Vivica A. Fox, Delta Spirit

S16 E02 • Wednesday, Sep 3, 2008 • Sep 3

Dr. Phil, Kevin Connolly, Adele

S16 E03 • Thursday, Sep 4, 2008 • Sep 4

Jerry O'Connell, Tim Gunn, Christian Lander

S16 E04 • Friday, Sep 5, 2008 • Sep 5

Howie Mandel, Nastia Liukin, Bon Iver

S16 E05 • Monday, Sep 8, 2008 • Sep 8

Keira Knightley, Tyler Perry, Bill Burr

S16 E06 • Tuesday, Sep 9, 2008 • Sep 9

Curtis Jackson, Kaitlin Olson, Gym Class Heroes

S16 E07 • Wednesday, Sep 10, 2008 • Sep 10

Serena Williams, Amy Sedaris, Meiko

S16 E08 • Thursday, Sep 11, 2008 • Sep 11

Eva Mendes, Luke Russert, The Fab Faux

S16 E09 • Friday, Sep 12, 2008 • Sep 12

Tonight's guests include Eva Mendes and Luke Russert. The Fab Faux perform.

Samuel L. Jackson, Ricky Gervais, Marc Broussard

S16 E10 • Monday, Sep 15, 2008 • Sep 15

Martha Stewart, Harland Williams, Kasey Chambers & Shane Nicholson

S16 E11 • Tuesday, Sep 16, 2008 • Sep 16

Tonight's guests include Martha Stewart and Harland Williams. Kasey Chambers & Shane Nicholson perform.

Ray Liotta, Marc Maron,Loudon Wainwright III

S16 E12 • Wednesday, Sep 17, 2008 • Sep 17

Anderson Cooper,Willie Nelson, Southside Johnny with La Bamba's Big Band

S16 E13 • Thursday, Sep 18, 2008 • Sep 18

Tonight's guests include Anderson Cooper and Willie Nelson. Southside Johnny with La Bamba's Big Band perform.

Ice-T, Dwayne Wade, Shane Mauss

S16 E14 • Friday, Sep 19, 2008 • Sep 19

Diane Lane, Patton Oswalt, Little Feat

S16 E15 • Monday, Sep 22, 2008 • Sep 22

Tonight's guests include Diane Lane and Patton Oswalt. Little Feat perform.

Billy Bob Thornton, Aasif Mandvi, Kenny Shopsin

S16 E16 • Tuesday, Sep 23, 2008 • Sep 23

Jaime Pressly, Little Britain, Lenka Kripac

S16 E17 • Wednesday, Sep 24, 2008 • Sep 24

Tonight's guests include Jamie Pressly and Little Britain. Lenka Kripac performs.

Julianne Moore, Zachary Levi, Jakob Dylan

S16 E18 • Thursday, Sep 25, 2008 • Sep 25

Tonight's guests include Julianne Moore and Zachary Levi. Jakob Dylan performs.

Brooke Shields, Robert Reich, Amos Lee

S16 E19 • Friday, Sep 26, 2008 • Sep 26

Tonight's guests include Brooke Shields and Robert Reich. Amos Lee performs.

Bill Maher, Simon Pegg, The Watson Twins

S16 E20 • Monday, Sep 29, 2008 • Sep 29

Tonight's guests include Bill Maher and Simon Pegg. The Watson Twins perform.

Julia Louis-Dreyfus, Michael Cera, Nate Bargatze

S16 E21 • Tuesday, Sep 30, 2008 • Sep 30

Robin Wright-Penn, Louis C.K., Department of Eagles

S16 E22 • Wednesday, Oct 1, 2008 • Oct 1

Tom Arnold, Flavor Flav, Ben Folds

S16 E23 • Thursday, Oct 2, 2008 • Oct 2

Tonight's guests include Tom Arnold and Flavor Flav. Ben Folds performs "You Don't Know Me" with Regina Spektor.

Greg Kinnear. J.J. Abrams, Nick Cave and the Bad Seeds

S16 E24 • Friday, Oct 3, 2008 • Oct 3

Felicity Huffman, Jason Sudeikis, Jenny Lewis

S16 E25 • Monday, Oct 6, 2008 • Oct 6

Russell Crowe, Alicia Keys, Death Cab for Cutie

S16 E26 • Tuesday, Oct 7, 2008 • Oct 7

Molly Shannon, Jason Ritter, Noah McCullough

S16 E27 • Wednesday, Oct 8, 2008 • Oct 8

Dennis Quaid, Lance Mackey, Sarah McLachlan

S16 E28 • Thursday, Oct 9, 2008 • Oct 9

Tonight's guests include Dennis Quaid and Lance Mackey. Sarah McLachlan performs.

LL Cool J, Oliver Stone, Dead Confederates

S16 E29 • Friday, Oct 10, 2008 • Oct 10

Tonight's guests include LL Cool J and Oliver Stone. Dead Confederates perform.

Christian Slater, Brian Posehn, Flobots

S16 E30 • Monday, Oct 13, 2008 • Oct 13

Tonight's guests include Christian Slater and Brian Posehn. Flobots perform.

Harry Connick, Jr., Richard Lewis, O.A.R.

S16 E31 • Tuesday, Oct 14, 2008 • Oct 14

Tonight's guests include Harry Connick Jr. and Richard Lewis. O.A.R. perform.

Bill Murray, Rob Corddry, Ray LaMontagne

S16 E32 • Wednesday, Oct 15, 2008 • Oct 15

Tonight's guests include Bill Murray and Rob Corddry. Ray LaMontagne performs.

Josh Brolin, Shaun Ellis & Helen Jeffs, Nikka Costa

S16 E33 • Thursday, Oct 16, 2008 • Oct 16

Tonight's guests include Josh Brolin and Shaun Ellis & Helen Jeffs. Nikka Costa performs.

Edward Norton, Chris "Ludacris" Bridges, Mike Birbiglia

S16 E34 • Friday, Oct 17, 2008 • Oct 17

Tonight's guests include Edward Norton and Chris "Ludacris" Bridges. Mike Birbiglia performs.

Charles Barkley, Justin Long, Annuals

S16 E35 • Monday, Oct 27, 2008 • Oct 27

Tonight's guests include Charles Barkley and Justin Long. The Annuals perform.

Tina Fey, Peter Sarsgaard, The Black Crowes

S16 E36 • Tuesday, Oct 28, 2008 • Oct 28

Tonight's guests include Tina Fey and Peter Sarsgaard. The Black Crowes perform.

Tracy Morgan, Paget Brewster, The Last Shadow Puppets

S16 E37 • Wednesday, Oct 29, 2008 • Oct 29

Tonight's guests include Tracy Morgan and Paget Brewster. The Last Shadow Puppets perform.

Jada Pinkett-Smith, Jason Biggs, Pink

S16 E38 • Thursday, Oct 30, 2008 • Oct 30

Tonight's guests include Jada Pinkett-Smith and Jason Biggs. Pink performs.

Mary-Kate Olsen, Will Forte, Tom Nardone

S16 E39 • Friday, Oct 31, 2008 • Oct 31

Tonight's guests include Mary-Kate Olsen, Will Forte and Tom Nardone.

Brian Williams, Bill Bellamy, The Decemberists

S16 E40 • Monday, Nov 3, 2008 • Nov 3

Tonight's guests include Brian Williams and Bill Bellamy. The Decemberists perform.

Dennis Hopper, Katt Williams, Phil Lesh & Friends

S16 E41 • Wednesday, Nov 5, 2008 • Nov 5

Tonight's guests include Dennis Hopper and Katt Williams. Phil Lesh & Friends perform.

Elvis Costello, Madeleine Albright, Lordi

S16 E42 • Thursday, Nov 6, 2008 • Nov 6

Tonight's guests include Elvis Costello and Madeleine Albright. Lordi perform.

Ricky Gervais, Vera Farmiga, Chromeo

S16 E43 • Friday, Nov 7, 2008 • Nov 7

Andy Richter, Jim Cramer, Tom Papa

S16 E44 • Monday, Nov 10, 2008 • Nov 10

Seth Green, Artie Lange, Conor Oberst & The Mystic Valley Band

S16 E45 • Tuesday, Nov 11, 2008 • Nov 11

Tonight's guests include Seth Green and Artie Lange. Conor Oberst & The Mystic Valley Band perform.

Tom Brokaw, Frank Caliendo, Joshua Radin

S16 E46 • Wednesday, Nov 12, 2008 • Nov 12

Tonight's guests include Tom Brokaw and Frank Caliendo. Joshua Radin performs.

Paul Rudd, John Stamos, Boz Scaggs

S16 E47 • Thursday, Nov 13, 2008 • Nov 13

Tonight's guests include Paul Rudd and John Stamos. Boz Scaggs performs.

Masi Oka, Alan Zweibel, Rock of Ages

S16 E48 • Friday, Nov 14, 2008 • Nov 14

Snoop Dogg, Brian Regan, Blitzen Trapper

S16 E49 • Monday, Nov 17, 2008 • Nov 17

Tonight's guests include Snoop Dogg and Brian Regan. Blitzen Trapper perform.

Jeff Corwin, Debra Messing, John Hodgman

S16 E50 • Tuesday, Nov 18, 2008 • Nov 18