Paul Giamatti

S16 E01 • Monday, Jan 3, 2011 • Jan 3

The media calls Barack Obama the "comeback kid," and Paul Giamatti says "rapscallion.

Sen. Kirsten Gillibrand

S16 E02 • Tuesday, Jan 4, 2011 • Jan 4

Republicans focus on 2010 issues, and Kirsten Gillibrand wants to reform the Senate filibuster rules.

Jimmy Wales

S16 E03 • Wednesday, Jan 5, 2011 • Jan 5

John McCain gets cranky, and Jimmy Wales imagines Wikipedia's relevance in 500 years.

Patton Oswalt

S16 E04 • Thursday, Jan 6, 2011 • Jan 6

Facebook refuses to disclose its financial results, and Patton Oswalt uses a prisoner ghostwriter.

Denis Leary

S16 E05 • Monday, Jan 10, 2011 • Jan 10

John Oliver reports on the Arizona shootings in his PJs, and Denis Leary discusses "Suck on This Year.

Colin Firth

S16 E06 • Tuesday, Jan 11, 2011 • Jan 11

John Oliver celebrates Verizon's iPhone announcement, and Colin Firth talks about "The King's Speech.

Tim Pawlenty

S16 E07 • Wednesday, Jan 12, 2011 • Jan 12

Members of Congress introduce gun legislation, and Tim Pawlenty defends Republican rhetoric.

Ron Howard

S16 E08 • Thursday, Jan 13, 2011 • Jan 13

John Hodgman makes NASCAR more exciting, and Ron Howard shares his enthusiasm for show business.

Peter Bergen

S16 E09 • Monday, Jan 17, 2011 • Jan 17

Michael Steele steps down as RNC chairman, and Peter Bergen talks about progress in Afghanistan.

Neil deGrasse Tyson

S16 E10 • Tuesday, Jan 18, 2011 • Jan 18

Jon promises Sarah Palin a classy conversation and reveals his love for Neil deGrasse Tyson.

Paul Clemens

S16 E11 • Wednesday, Jan 19, 2011 • Jan 19

Glenn Beck appears on the "Today" show, and Paul Clemens discusses blue-collar decline.

Kambiz Hosseini & Saman Arbabi

S16 E12 • Thursday, Jan 20, 2011 • Jan 20

Steve Cohen compares Republicans to Nazis, and Kambiz Hosseini and Saman Arbabi call Jon a prophet.

Anand Giridharadas

S16 E13 • Monday, Jan 24, 2011 • Jan 24

Wyatt Cenac dons a parrot suit in Mississippi, and Anand Giridharadas tells Jon the truth.

James Franco

S16 E14 • Tuesday, Jan 25, 2011 • Jan 25

A reporter searches for homeless talent, and Jon composes an ode to James Franco's Oscar nomination.

Jonathan Alter

S16 E15 • Wednesday, Jan 26, 2011 • Jan 26

Michele Bachmann looks off camera, and Jonathan Alter examines Obama's plans for the future.

T. Boone Pickens

S16 E16 • Thursday, Jan 27, 2011 • Jan 27

Bill O'Reilly defends his Nazi analogies, and T. Boone Pickens wants America on an energy plan.

Bill Gates

S16 E17 • Monday, Jan 31, 2011 • Jan 31

Egyptian forces use American tear gas canisters, and Bill Gates works on curing polio.

Michael Steele

S16 E18 • Tuesday, Feb 1, 2011 • Feb 1

Conservatives turn into political hypochondriacs, and Michael Steele must prove his identity.

Matthew Perry

S16 E19 • Wednesday, Feb 2, 2011 • Feb 2

Republicans close the rape loophole, and Matthew Perry talks about his happy friend.

Adm. Michael Mullen

S16 E20 • Thursday, Feb 3, 2011 • Feb 3

Justin Bieber switches bodies with Jon, and Mike Mullen talks about the crisis in Egypt.

Edward Glaeser

S16 E21 • Monday, Feb 14, 2011 • Feb 14

January Jones

S16 E22 • Tuesday, Feb 15, 2011 • Feb 15

Brian Williams

S16 E23 • Wednesday, Feb 16, 2011 • Feb 16

Anchor and Managing Editor, NBC Nightly News. The award-winning journalist and friend-of-the-show stops by.

Ed Gillespie

S16 E24 • Thursday, Feb 17, 2011 • Feb 17

Lisa Ling

S16 E25 • Monday, Feb 21, 2011 • Feb 21

Anderson Cooper

S16 E26 • Tuesday, Feb 22, 2011 • Feb 22

Donald Rumsfeld

S16 E27 • Wednesday, Feb 23, 2011 • Feb 23

Austan Goolsbee

S16 E28 • Thursday, Feb 24, 2011 • Feb 24

Howard Stern

S16 E29 • Monday, Feb 28, 2011 • Feb 28

CNN anchors take viewer requests, and Howard Stern hopes to talk to Charlie Sheen.

Prince Zeid Ra'ad

S16 E30 • Tuesday, Mar 1, 2011 • Mar 1

Prince Zeid Ra'ad Representative, The Hashemite Kingdom of Jordan The U.N. representative of Jordan discusses King Abdullah II's new book, "Our Last Best Chance.

Allison Stanger

S16 E31 • Wednesday, Mar 2, 2011 • Mar 2

Diane Ravitch

S16 E32 • Thursday, Mar 3, 2011 • Mar 3

Sen. Rand Paul

S16 E33 • Monday, Mar 7, 2011 • Mar 7

Brian Christian

S16 E34 • Tuesday, Mar 8, 2011 • Mar 8

Author Brian Christian ('The Most Human Human: What Talking with Computers Teaches Us About What It Means to Be Alive').

Aaron Eckhart

S16 E35 • Wednesday, Mar 9, 2011 • Mar 9

From 'Battle: Los Angeles,' actor Aaron Eckhart.

Trey Parker & Matt Stone

S16 E36 • Thursday, Mar 10, 2011 • Mar 10

'South Park,' creators Trey Parker and Matt Stone.

Sarah Vowell

S16 E37 • Monday, Mar 21, 2011 • Mar 21

Author, "Unfamiliar Fishes." The author discusses her new book about American colonization of Hawaii in the 1800s.

T.J. English

S16 E38 • Tuesday, Mar 22, 2011 • Mar 22

The author of "The Savage City" discusses his new book about murder and corruption in New York City during the 1960s and 70s.

Richard Lewis

S16 E39 • Wednesday, Mar 23, 2011 • Mar 23

Bret Baier

S16 E40 • Thursday, Mar 24, 2011 • Mar 24

Dr. Mansour O.El-Kikhia

S16 E41 • Monday, Mar 28, 2011 • Mar 28

Republicans want to lower the corporate tax rate, and Mansour O. El-Kikhia discusses Libya.

Miguel Nicoleles

S16 E42 • Tuesday, Mar 29, 2011 • Mar 29

Joe Biden works the room at a war speech, and Miguel Nicolelis helps paralyzed people walk again.

Jake Gyllenhaal

S16 E43 • Wednesday, Mar 30, 2011 • Mar 30

Republicans appeal to their narrow base, and Jake Gyllenhaal considers marrying a stranger.

Norm MacDonald

S16 E44 • Thursday, Mar 31, 2011 • Mar 31

CIA operatives might arm Libyan rebels, and Norm Macdonald wants to blow up his stupid high school.

Billy Crystal

S16 E45 • Monday, Apr 4, 2011 • Apr 4

The comedian and actor discusses his role as a vampire in an upcoming Funny Or Die short.

Colin Quinn

S16 E46 • Tuesday, Apr 5, 2011 • Apr 5

The comedian discusses his one-man Broadway show and special on HBO.

Mike Huckabee

S16 E47 • Wednesday, Apr 6, 2011 • Apr 6

The former governor of Arkansas discusses his views on government, families and his latest book.

Jamie Oliver

S16 E48 • Thursday, Apr 7, 2011 • Apr 7

The chef talks about healthy cooking habits and the upcoming season of his Emmy-winning series.

Foo Fighters

S16 E49 • Monday, Apr 11, 2011 • Apr 11

The rock band visits to perform a song from their latest album.

Governor Deval Patrick

S16 E50 • Tuesday, Apr 12, 2011 • Apr 12

The governor of Massachusetts discusses his rise from poverty and what gives him hope for America's future.