Julie Bowen / Jonathan Winters / Priscilla Ahn

S05 E01 • Monday, Sep 1, 2008 • Sep 1 • 1h

Katey Sagal / Nathan Fillion

S05 E02 • Tuesday, Sep 2, 2008 • Sep 2 • 1h

Julie Chen / Maria Bello / Shelby Lynne

S05 E03 • Wednesday, Sep 3, 2008 • Sep 3 • 1h

Eva Longoria / Neal McDonough

S05 E04 • Thursday, Sep 4, 2008 • Sep 4 • 1h

Kal Penn / Gabe Dixon Band

S05 E05 • Friday, Sep 5, 2008 • Sep 5 • 1h

Julie Chen / Neil Patrick Harris / Sophia Myles

S05 E06 • Monday, Sep 8, 2008 • Sep 8 • 1h

Craig welcomes TV host Julie Chen for a "Big Brother" update, actor Neil Patrick Harris and actress Sophia Myles.

Russell Brand / Margaret Cho

S05 E07 • Tuesday, Sep 9, 2008 • Sep 9 • 1h

Alice Cooper / AnnaLynne McCord

S05 E08 • Wednesday, Sep 10, 2008 • Sep 10 • 1h

Lynn Ferguson / Lance Morrow

S05 E09 • Thursday, Sep 11, 2008 • Sep 11 • 1h

Craig welcomes his sister, actress Lynn Ferguson and author Lance Morrow.

Seann William Scott / Lena Heady

S05 E10 • Friday, Sep 12, 2008 • Sep 12 • 1h

Craig welcomes actress Lena Heady. Sean William Scott is stuck in traffic, so he welcomes segment producer Lisa Ammerman instead.

Julie Chen / Jason Biggs / The Ting Tings

S05 E11 • Monday, Sep 15, 2008 • Sep 15 • 1h

Paulina Porizkova / Ken Tucker / Tally Hall

S05 E12 • Tuesday, Sep 16, 2008 • Sep 16 • 1h

Alan Alda / Illeana Douglas

S05 E13 • Wednesday, Sep 17, 2008 • Sep 17 • 1h

Jason Segel / Dr Dog / Steve Hofstetter

S05 E14 • Thursday, Sep 18, 2008 • Sep 18 • 1h

Kristen Bell / Josh Radnor

S05 E15 • Friday, Sep 19, 2008 • Sep 19 • 1h

Craig welcomes actress Kristen Bell, actor Josh Radnor. With special feature of "Murder, She Wrote" with Samuel L. Jackson.

Denis Leary / Marianne Jean-Baptiste

S05 E16 • Monday, Sep 22, 2008 • Sep 22 • 1h

John Krasinski / Lisa Masterson

S05 E17 • Tuesday, Sep 23, 2008 • Sep 23 • 1h

Michael Clarke Duncan / Shirley Manson / Jamie Lidell

S05 E18 • Wednesday, Sep 24, 2008 • Sep 24 • 1h

Tim Gunn / Elizabeth Reaser

S05 E19 • Thursday, Sep 25, 2008 • Sep 25 • 1h

Drew Carey / Tony Parker / Lady Antebellum

S05 E20 • Friday, Sep 26, 2008 • Sep 26 • 1h

Melina Kanakaredes / Gina Carano / Amy Macdonald

S05 E21 • Monday, Sep 29, 2008 • Sep 29 • 1h

Tim Daly / Anna Friel / Alice Cooper

S05 E22 • Tuesday, Sep 30, 2008 • Sep 30 • 1h

Jennifer Love Hewitt / Jim Parsons

S05 E23 • Wednesday, Oct 1, 2008 • Oct 1 • 1h

Lauren Graham / Patrick Pedraja / Michael Franti & Spearhead

S05 E24 • Thursday, Oct 2, 2008 • Oct 2 • 1h

Margaret Cho / Randy Newman / Randy Newman

S05 E25 • Friday, Oct 3, 2008 • Oct 3 • 1h

Seth Green / Betty White / Smothers Brothers

S05 E26 • Monday, Oct 6, 2008 • Oct 6 • 1h

Thandie Newton / Barry Sonnenfeld / Jim Bianco

S05 E27 • Tuesday, Oct 7, 2008 • Oct 7 • 1h

Craig welcomes actress Thandie Newton and director Barry Sonnenfeld. Musical Guest Jim Bianco performs "I Got A Thing For You".

Rufus Sewell / Natasha Bedingfield

S05 E28 • Wednesday, Oct 8, 2008 • Oct 8 • 1h

Russell Crowe / Jennifer Esposito

S05 E29 • Thursday, Oct 9, 2008 • Oct 9 • 1h

Matt Lucas & David Walliams / Tom Morello

S05 E30 • Friday, Oct 10, 2008 • Oct 10 • 1h

Dee Dee Myers / Noah Emmerich

S05 E31 • Monday, Oct 20, 2008 • Oct 20 • 1h

Rachael Ray / Leanne Marshall / Laura Marling

S05 E32 • Tuesday, Oct 21, 2008 • Oct 21 • 1h

Chris Matthews / Christopher Mintz-Plasse

S05 E33 • Wednesday, Oct 22, 2008 • Oct 22 • 1h

John Malkovich / Little Jackie

S05 E34 • Thursday, Oct 23, 2008 • Oct 23 • 1h

Mo'Nique / Bill Santiago / Lenka

S05 E35 • Friday, Oct 24, 2008 • Oct 24 • 1h

Kathy Griffin / Carl Bernstein

S05 E36 • Monday, Oct 27, 2008 • Oct 27 • 1h

Pepe the King Prawn / Saffron Burrows

S05 E37 • Tuesday, Oct 28, 2008 • Oct 28 • 1h

Ben Stein / Parminder Nagra / The New York Dolls

S05 E38 • Wednesday, Oct 29, 2008 • Oct 29 • 1h

Kevin Smith / Kaitlin Olson

S05 E39 • Thursday, Oct 30, 2008 • Oct 30 • 1h

Lauren Graham / The Damned

S05 E40 • Friday, Oct 31, 2008 • Oct 31 • 1h

Bill Maher

S05 E41 • Monday, Nov 3, 2008 • Nov 3 • 1h

Paris Hilton / Drew Pinsky

S05 E42 • Wednesday, Nov 5, 2008 • Nov 5 • 1h

Elizabeth Banks / Jay Mohr

S05 E43 • Thursday, Nov 6, 2008 • Nov 6 • 1h

Christian Slater / Luke Dempsey / Eric Hutchinson

S05 E44 • Friday, Nov 7, 2008 • Nov 7 • 1h

Mark Harmon / Ron White

S05 E45 • Monday, Nov 10, 2008 • Nov 10 • 1h

Coolio / Tom Dreesen / Tim Reid

S05 E46 • Tuesday, Nov 11, 2008 • Nov 11 • 1h

Seann William Scott / Kathy Kinney

S05 E47 • Wednesday, Nov 12, 2008 • Nov 12 • 1h

Andy Richter / Cold War Kids

S05 E48 • Thursday, Nov 13, 2008 • Nov 13 • 1h

Jim Parsons / Ray Davies

S05 E49 • Friday, Nov 14, 2008 • Nov 14 • 1h

Poppy Montgomery / Nick Hornby

S05 E50 • Monday, Nov 17, 2008 • Nov 17 • 1h