Robin Thicke

S04 E01 • Monday, Jan 4, 2010 • Jan 4 • 30m

We're starting off the new year with Robin Thicke and his Sex Therapy...like father like son. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Guy Branum are on the panel.

Mary J. Blige

S04 E02 • Tuesday, Jan 5, 2010 • Jan 5 • 30m

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

Holly Madison

S04 E03 • Wednesday, Jan 6, 2010 • Jan 6 • 30m

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

Joel David Moore

S04 E04 • Thursday, Jan 7, 2010 • Jan 7 • 30m

Holly Madison is dropping on by her old E! family today...we've missed her, too. Comedian Donnel Rawlings, comedian Heather McDonald and comedian Gary Valentine.

Giuliana & Bill Rancic

S04 E05 • Monday, Jan 11, 2010 • Jan 11 • 30m

Word on the street is Giuliana and Bill Rancic are trying to have a baby. What're the odds that we'll get any sort of big announcement? Comedian Brad Wollack, comedian Natasha Leggero and comedian Matt Braunger.

Aisha Tyler

S04 E06 • Tuesday, Jan 12, 2010 • Jan 12 • 30m

We welcome back the very funny Aisha Tyler, from the new show Archer. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

Amy Brenneman

S04 E07 • Wednesday, Jan 13, 2010 • Jan 13 • 30m

Amy Brenneman of Private Practice stops by, perhaps with some doctorly advice. Comedian John Caparulo, comedian Jen Kirkman and comedian Dan Levy.

Snooki, Pauly D and The Situation

S04 E08 • Thursday, Jan 14, 2010 • Jan 14 • 30m

Fist pumps all around for Jersey Shore's Snooki, Pauly D and The Situation. Comedian Chris Franjola, comedian Whitney Cummings and TV personality Ross Mathews.

David Arquette

S04 E09 • Monday, Jan 18, 2010 • Jan 18 • 30m

David Arquette is back and telling us all about his new play The Female of the Species and the Golden Globes! Comedians Michelle Collins and Randy and Jason Sklar

Adrianne Palicki

S04 E10 • Tuesday, Jan 19, 2010 • Jan 19 • 30m

Clear eyes, full hearts, can't lose with Legion's Adrianne Palicki (aka FNL's Tyra). Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Eric Price.

Kaley Cuoco

S04 E11 • Wednesday, Jan 20, 2010 • Jan 20 • 30m

Who wouldn't be stoked that Kaley Cuoco from the megapopular Big Bang Theory is here? Comedian Heather McDonald, TV personality Ross Mathews and comedian Lavell Crawford.

James Van Der Beek

S04 E12 • Thursday, Jan 21, 2010 • Jan 21 • 30m

James Van Der Beek is in the new movie Formosa Betrayed and popping up all over TV—even here! E!'s own Michael Yo, comedian Sarah Colonna and comedian Guy Branum.

Katharine McPhee

S04 E13 • Monday, Jan 25, 2010 • Jan 25 • 30m

Jill Scott

S04 E14 • Tuesday, Jan 26, 2010 • Jan 26 • 30m

Dax Shepard

S04 E15 • Wednesday, Jan 27, 2010 • Jan 27 • 30m

Staff Book Club

S04 E16 • Thursday, Jan 28, 2010 • Jan 28 • 30m

Camila Alves

S04 E17 • Monday, Feb 1, 2010 • Feb 1 • 30m

Andy Whitfield

S04 E18 • Tuesday, Feb 2, 2010 • Feb 2 • 30m

Shorty Rossi

S04 E19 • Wednesday, Feb 3, 2010 • Feb 3 • 30m

Julie Benz

S04 E20 • Thursday, Feb 4, 2010 • Feb 4 • 30m

Ozzy Osbourne

S04 E21 • Monday, Feb 8, 2010 • Feb 8 • 30m

Amanda Seyfried

S04 E22 • Tuesday, Feb 9, 2010 • Feb 9 • 30m

Dave Salmoni

S04 E23 • Wednesday, Feb 10, 2010 • Feb 10 • 30m

We're beyond pleased to welcome back our animal guy Dave Salmoni and his new animal friends. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Mo Mandel.

Channing Tatum

S04 E24 • Friday, Feb 12, 2010 • Feb 12 • 30m

Kate Flannery

S04 E25 • Monday, Feb 15, 2010 • Feb 15 • 30m

We get down to business with The Office's Kate Flannery. Comedian Loni Love, comedian Dan Levy and comedian Whitney Cummings.

Jackie Collins

S04 E26 • Tuesday, Feb 16, 2010 • Feb 16 • 30m

Things get really scandalous when author Jackie Collins stops by with her new book, Poor Little Bitch Girl. Comedian Chris Hardwick, comedian Jen Kirkman and comedian Jo Koy.

Lisa Edelstein

S04 E27 • Wednesday, Feb 17, 2010 • Feb 17 • 30m

Lisa Edelstein from House is back again...Wait, so who's running Princeton Plainsboro? Comedian Josh Wolf, comedian Heather McDonald and comedian Ryan Stout.

Eli Roth

S04 E28 • Thursday, Feb 18, 2010 • Feb 18 • 30m

Keshia Knight Pulliam

S04 E29 • Monday, Feb 22, 2010 • Feb 22 • 30m

House of Payne's Keshia Knight Pulliam is one hard working lady; Dr. Huxtable would be so proud. Comedian Loni Love, TV personality Rove McManus and comedian Michelle Collins

Danica Patrick

S04 E30 • Tuesday, Feb 23, 2010 • Feb 23 • 30m

We're pretty thrilled that Danica Patrick makes a pit stop over at Chelsea Lately today. Comedian Josh Wolf, comedian Whitney Cummings and comedian Jo Koy.

Radha Mitchell

S04 E31 • Wednesday, Feb 24, 2010 • Feb 24 • 30m

Things might get wild with Radha Mitchell star of the new thrilling horror movie The Crazies. Comedian John Caparulo, comedian Bill Bellamy and actress-comedian Arden Myrin.

Parker Posey

S04 E32 • Thursday, Feb 25, 2010 • Feb 25 • 30m

The Chelsea Lately cast do a Kardashian skit. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

Sean William Scott

S04 E33 • Monday, Mar 1, 2010 • Mar 1 • 30m

From the new movie Cop Out we've got Seann William Scott in our custody today. Comedian Chris Hardwick and Comedians Randy and Jason Sklar.

Kendra & Hank Baskett

S04 E34 • Tuesday, Mar 2, 2010 • Mar 2 • 30m

Kendra and Hank Baskett are here to tell us all about the spellbinding new season of Kendra. E!'s own Michael Yo, comedian Sarah Colonna and comedian Jo Koy.

Single Staffers, Handler Edition

S04 E35 • Wednesday, Mar 3, 2010 • Mar 3 • 30m

Please enjoy a very special Handler Edition of Single Staffers. Comedian Matt Bruanger, comedian Heather McDonald and comedian Moshe Kasher.

Gabourey Sidibe

S04 E36 • Thursday, Mar 4, 2010 • Mar 4 • 30m

From Precious, the Academy Award-nominated Gabourey Sidibe is here. TV personality Ross Mathews, comedian Christina Pazsitzky and comedian Guy Branum.

Kevin McKidd

S04 E37 • Monday, Mar 8, 2010 • Mar 8 • 30m

Someone got some time away from the O.R., Grey's Anatomy's Kevin McKidd is here. Comedian John Caparulo, comedian Arden Myrin and comedian Chris Franjola.

Chelsea Chelsea Bang Bang

S04 E38 • Tuesday, Mar 9, 2010 • Mar 9 • 30m

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

Amy Ryan

S04 E39 • Wednesday, Mar 10, 2010 • Mar 10 • 30m

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

Pretty Wild Cast

S04 E40 • Thursday, Mar 11, 2010 • Mar 11 • 30m

Alexis Neiers, Gabrielle Neiers and Tess Taylor are here from their aptly titled new series on E! Pretty Wild. Comedian Brad Wollack, comedian Dan Levy and comedian Josh Wolf.

Shenae Grimes

S04 E41 • Monday, Mar 15, 2010 • Mar 15 • 30m

90210's Shenae Grimes is here to give us the deets on all things West Beverly. Comedian Bobby Lee, comedian T.J. Miller and comedian Whitney Cummings.

Rachael Harris

S04 E42 • Tuesday, Mar 16, 2010 • Mar 16 • 30m

From the highly anticipated Diary of a Wimpy Kid, the purely entertaining Rachael Harris is here. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

Avril Lavigne

S04 E43 • Wednesday, Mar 17, 2010 • Mar 17 • 30m

We catch up with Avril Lavigne, who sings "Alice," the title song from Tim Burton's Alice in Wonderland. Comedian Sarah Colonna, comedian/TV host Rove McManus and comedian Mo Mandel.

Duane "Dog" Chapman

S04 E44 • Thursday, Mar 18, 2010 • Mar 18 • 30m

We're so thrilled to welcome the author of Where Mercy Is Shown, Mercy Is Given, Dog the Bounty Hunter. Comedian John Caparulo, comedian Heather McDonald and TV personality Ross Mathews.

Kelly Cutrone

S04 E45 • Monday, Mar 22, 2010 • Mar 22 • 30m

Scott Wolf

S04 E46 • Tuesday, Mar 23, 2010 • Mar 23 • 30m

Crispin Glover

S04 E47 • Wednesday, Mar 24, 2010 • Mar 24 • 30m

Blake Shelton

S04 E48 • Thursday, Mar 25, 2010 • Mar 25 • 30m

Ludacris

S04 E49 • Monday, Mar 29, 2010 • Mar 29 • 30m

Ludacris is back with his new album Battle of the Sexes and this time he's bringing drinks. Comedian Ben Gleib, comedian Natasha Leggero and comedian Guy Branum.

Johnny Weir

S04 E50 • Tuesday, Mar 30, 2010 • Mar 30 • 30m

Johnny Weir is here, and unfortunately our show is not "on ice" this week. Comedian Jo Koy, comedian Lil JJ and comedian Sarah Colonna.